Initial Investigation Protocol
Conventional laboratory analysis has involved serum protein electrophoresis (SPE) or capillary zone electrophoresis (CZE) plus urine protein electrophoresis (UPE) (for Light Chain Multiple Myeloma, Bence Jones Protein), followed by immunofixation electrophoresis (IFE).
Now, with Freelite, a more sensitive and specific protocol can be implemented to significantly increase detection of B cell dyscrasia.
In the initial laboratory investigation a strategy of performing serum protein electrophoresis and serum Freelite analysis will allow identification of all significant monoclonal proteins and negate the requirement for urine samples for screening.
Laboratory Investigation with Freelite
Requests for investigation of multiple myeloma require a serum sample. The sample should be analysed by both SPE and Freelite kappa and lambda assays, as proposed below:
Evidence for the Investigation Protocol
Clinical Evidence for the Utility of Freelite
Serum Free Light Chain Information Pack
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